David A Bluemke, MD, PhD

Rationale Chronic obstructive pulmonary disease (COPD) and heart failure with preserved ejection fraction (HFpEF) have both shown increased prevalence, morbidity and mortality over the past decades. Previous studies have found impaired left ventricular filling in COPD and emphysema. In addition, pulmonary vascular changes have been linked to the impaired filling suggesting an upstream mechanism that remains unclear. 4D-flow MRI (3D+ time) is a reliable and reproducible imaging technique that gives comprehensive, time-resolved hemodynamic assessment. We aimed to use 4D-flow derived measurements to characterize the cardiopulmonary hemodynamic interactions in COPD. Methods SPIROMICS is a multicenter, longitudinal case-control study that recruited COPD cases with 20+ packyears of smoking and controls. SPIROMICS HF is adding detailed cardiac phenotyping including cardiac MRIs in up …

Cardiovascular magnetic resonance (CMR) imaging has become an invaluable clinical and research tool. Starting from the discovery of nuclear magnetic resonance, this article provides a brief overview of the key developments that have led to CMR as it is today, and how it became the modality of choice for large-scale population studies.

BackgroundOur understanding of the specific aspects of vascular contributions to dementia remains incomplete. We aim to identify the correlates of incident dementia in a multi-ethnic cardiovascular cohort.MethodsA total of 6806 participants with follow-up data for incident dementia were included. Probable dementia diagnoses were identified using hospitalization discharge diagnoses according to the International Classification of Diseases Codes (ICD). We used Random Survival Forest analysis to identify the correlates of incident dementia from among 198 variables collected at the baseline MESA exam entailing demographic risk factors, past medical history, anthropometric measurements, laboratory markers, electrocardiogram, cardiac and aortic magnetic resonance imaging, coronary artery calcium and liver fat content. Death and stroke were considered competing risks.ResultsOver 14 years of follow-up, 326 …

RATIONALE Chronic obstructive pulmonary disease (COPD) and heart failure with preserved ejection fraction (HFpEF) are leading causes of hospitalization and mortality and often overlap clinically. The heart and lungs have developmental, molecular, anatomical and physiologic linked yet are often studied separately. We provide initial completion and reproducibility measures of echocardiography and cardiopulmonary MRI measures in a large multicenter study of cardiac

More evidence to support greater use of 4D flow cardiac MRI. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus Search life-sciences literature (43,739,637 articles, preprints and more) Search Advanced search Feedback This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Abstract Full text More evidence to support greater use of 4D flow cardiac MRI. Bluemke DA 1 , Kawel-Boehm N 2 Author information Affiliations 1. Department of Radiology, University of Wisconsin, WI 53792, USA. (1 author) 2. Department of Radiology, Kantonsspital Graubuenden, Chur 7000, Switzerland. (1 author) Diagnostic and Interventional …

Purpose Metronome-paced tachypnea (MPT) is a validated technique to induce dynamic hyperinflation assessed with spirometry. But spirometry cannot directly measure end-expiratory lung volume (EELV), which is a key metric of hyperinflation. We implemented MPT with cine pulmonary MRI to test if MRI measured dynamic hyperinflation relates to hyperinflation in COPD. Methods and Materials SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) is a prospective cohort study that has enrolled 2,981 participants across four strata (never smokers, smokers without COPD, mild/moderate COPD, and severe COPD) with the goal of identifying new COPD subgroups and intermediate markers of disease progression. The SPIROMICS Heart Failure (HF) Study is evaluating cardiopulmonary interactions in COPD. During 2D coronal cine pulmonary MRI, participants at one site performed …

Trauma survivors show marked differences in the severity and persistence of post-traumatic stress disorder (PTSD) symptoms. Early symptoms subside in most, but persist as acute and chronic PTSD in a significant minority. The underlying molecular mechanisms or outcome predictors determining these differences are not known. Molecular markers for identifying any mental disorder are currently lacking. Gene expression profiling during the triggering and development of PTSD may be informative of its onset and course. We used oligonucleotide microarrays to measure peripheral blood mononuclear cell (PBMC) gene expression of trauma survivors at the emergency room and 4 months later. Gene expression signatures at both time points distinguished survivors who met DSM-IV diagnostic criteria for PTSD at 1 and 4 months, from those who met no PTSD criterion. Expression signatures at both time points …

Rationale Chronic obstructive pulmonary disease (COPD) and emphysema are associated with pulmonary hemodynamic changes possibly related to increased intra-thoracic pressure during expiration, altering venous return into the thorax. 4D (3D+ time) flow MRI has emerged as a useful and reliable imaging technique to comprehensively capture dynamic blood velocity vectors in the heart and vessels over a large imaging volume, thus enabling advanced hemodynamic analysis. Here we use 4D flow MRI to quantify hemodynamic parameters of venous return to the right heart in patients with COPD and controls. Methods and Materials 4D Flow MRI datasets were acquired and analyzed within the SPIROMICS Heart Failure (HF) Study, which is evaluating cardiopulmonary interactions in COPD. COPD severity were defined by GOLD criteria. FEV1 and FVC were assessed via spirometry. Data processing was …