Mostafa A. El-Sayed

A novel series of triazole–benzohydrazone hybrids was efficiently designed and synthesized as antiproliferative agents, targeting different kinases. All compounds were screened via the National Cancer Institute (NCI) against 60 cancer cell lines, where compounds 16, 17, and 18 exhibited growth inhibition percent (GI%) of various leukemia subpanels with values of 70.33%, 64.13%, and 76.03%, respectively. Compound 18 showed broad‐spectrum antiproliferative efficacy toward most cancer cells, with outstanding potency regarding melanoma (MALME‐3M GI% = 101.82%) and breast cancer cell lines (MCF7 GI% = 85.87%), while proving safe toward the WI‐38 normal cell line, compared to doxorubicin. Multikinase investigation including vascular endothelial growth factor receptor 2 (VEGFR‐2), mesenchymal epithelial transition factor (c‐Met), proto‐oncogene B‐Raf, mitogen‐activated protein kinase kinase …

An exemplary embodiment of the present invention provides a system for forming ammonia, the system comprising: an anode; a cathode in electrical communication with the anode; and a catalyst material positioned in an electrical communication pathway between the cathode and the anode, the catalyst material comprising a plurality of nanoparticles comprising at least one of a conductor and a semiconductor, each of the nanoparticles comprising an interior cavity, wherein the system is configured to use nitrogen and water to generate ammonia.

A novel series of 2-phenylbenzimidazole scaffold was designed as dual tyrosine kinase inhibitors based on targeted chemotherapy. All compounds were assessed for their antiproliferative activity against 60 NCI-cancer cell lines, where four compounds 14, 15, 17, and 18 showed superb growth inhibition values, and meanwhile proved safe towards WI-38 normal cells (IC50 range of 39.14–86.66 µM) compared to Doxorubicin (IC50= 6.72 µM). Hence, they were further in vitro evaluated for dual inhibition of Aurora A and CDK-6 enzymes after kinase selectivity profiling, using an extensive docking study to filter off-target enzymes. The four compounds displayed dual enzymatic inhibition, with compounds 14 and 18 being even more potent regarding CDK-6 with IC50 values of 0.197 µM and 0.172 µM, respectively, than Staurosporine (IC50=0.319 µM), and highly potent towards Aurora A, with IC50 values of 74 nM and …

Certain sulfathiazole‐triazolo chalcone hybrids were identified as anticancer agents with dual vascular endothelial growth factor receptor‐2 (VEGFR‐2)/epidermal growth factor receptor (EGFR) kinase inhibitory effect. All of the compounds were evaluated for their cytotoxic activity against the MCF‐7 and HepG‐2 tumor cell lines. Compounds 11g, 11h, and 11j exhibited the most potent antiproliferative activity against both cancer cell lines, with good safety toward WI‐38 normal cells. Thus, they were further assessed for VEGFR‐2 inhibitory activity. They have suppressed VEGFR‐2 enzyme at IC50 of 0.316, 0.076, and 0.189 µM, respectively in comparison to sorafenib (IC50 = 0.035 µM). EGFR enzyme inhibition was further screened for the most potent inhibitors, 11h and 11j, where they displayed enhanced potency with IC50 of 0.085 and 0.108 µM, respectively, compared to erlotinib (IC50 = 0.037 µM …

Two series of new benzimidazole derivatives were designed and synthesized. The antiproliferative activity of the new derivatives was screened against five human cancer cell lines namely; HepG-2, MCF-7, PC-3, HCT-116 and Hela. Relative to Doxorubicin (IC50 = 6.72 µM), compounds 18 and 19 showed broad spectrum anticancer effect against all the tested cancer cell lines, with IC50 range of 5.16–20.35 µM, however they were safe to WI-38 normal cells with IC50 of 32.61 µM and 50.62 µM, respectively. Inspection of human TopoII inhibitory activity disclosed that compound 18 was the most potent (IC50 = 6.9 µM) compared to Staurosporine (IC50 = 4.64 µM). Further mechanistic studies implied that compound 18 triggered the apoptotic death of MCF-7 cells via decreasing Bcl-2, activating caspases 8 and 9, and increasing the accumulation of ROS. In addition, it caused cell cycle arrest at the G1-phase and …

Combined chemo-photothermal therapy (CT-PTT) based on gold nanorods (AuNRs) loaded with chemotherapies has been recently introduced as a promising anticancer therapy with relatively lower side effects and higher efficacy over individual therapeutic approaches. We fabricated β-cyclodextrin-based nanosponges encapsulating PEGylated gold nanorods and doxorubicin (DOX), AuNR-S-PEG.β-CD NS-DOX, comprehensively characterized it using TEM, SEM, FE-SEM, FITR, and DLS and then evaluated it for CT-PTT versus the respective photothermal, AuNR-S-PEG.β-CD NS, and chemotherapy DOX. The synthesized AuNR-S-PEG.β-CD NS nanocomposite exhibited high photothermal conversion efficiency and high drug loading capacity based on the porous structure of the nanosponges. The drug-loaded nanocomposites, AuNR-S-PEG.β-CD NS-DOX, showed pH/NIR dual-responsive drug release …

The effect of deformation in the scattering and reaction of a C 9 radioactive beam by protons and C 12 is investigated within the relativistic impulse approximation and a modified Glauber model whose amplitude involved the combined effects of phase variation, higher momentum transfer components, Pauli blocking, and finite range. Spherical and deformed relativistic mean field densities are used. Using the proton scattering experiment by C 9 as well as interaction cross section data, the proton and neutron root mean square (rms) radii and deformations are extracted. It is found that deformation strongly affects the scattering cross section and polarization at medium and large angles, where the second and third peaks are reproduced by a deformed density. The polarization is inverted at the peaks by deformation. The measured angular distribution of the proton by a C 9 beam at 277–300 MeV/u as well as the …

Quaternion algebra has been used to apply the fractional Fourier transform (FrFT) to color images in a comprehensive approach. However, the discrete fractional random transform (DFRNT) with adequate basic randomness remains to be examined. This paper presents a novel multistage privacy system for color medical images based on discrete quaternion fractional Fourier transform (DQFrFT) watermarking and three-dimensional chaotic logistic map (3D-CLM) encryption. First, we describe quaternion DFRNT (QDFRNT), which generalizes DFRNT to handle quaternion signals effectively, and then use QDFRNT to perform color medical image adaptive watermarking. To efficiently evaluate QDFRNT, this study derives the relationship between the QDFRNT of a quaternion signal and the four components of the DFRNT signal. Moreover, it uses the human vision system’s (HVS) masking qualities of edge, texture, and …

Multi-target inhibitors represent useful anticancer agents with superior therapeutic attributes. Here in, two novel series of benzimidazole-triazole hybrids were designed, synthesised as multi-target EGFR, VEGFR-2 and Topo II inhibitors, and evaluated for anticancer activity. Compounds 5a and 6g were the most potent analogues against four cancer cell lines, HepG-2, HCT-116, MCF-7 and HeLa, and were further evaluated for EGFR, VEGFR-2, and Topo II inhibition. Compound 5a was especially good inhibitor for EGFR (IC50 = 0.086 µM) compared to Gefitinib (IC50 = 0.052 µM), moderate VEGFR-2 inhibitor (IC50 = 0.107 µM) compared to Sorafenib (IC50 = 0.0482 µM), and stronger Topo II inhibitor (IC50 = 2.52 µM) than Doxorubicin (IC50 = 3.62 µM). Compound 6g exhibited moderate EGFR and VEGFR-2 inhibition and weaker Topo II inhibition. DNA binding assay, cell cycle analysis, apoptotic …

The present study discloses the synthesis of certain sulfathiazole-triazole hybrids. Versatile sulfonamide derivatives were unexpectedly obtained during the course of synthesis upon treatment with various amounts of hydrazine hydrate, throughout either ring-cleavage or complete detachment of the thiazole moiety. Assorted hydrazide intermediates were obtained, and utilized to form a diversity of sulfonamide-based scaffolds, tagged with triazole and hydrazone/pyrazole functionalities, aiming to be further investigated for cytotoxic activity. All the synthesized compounds were characterized by 1H-NMR and 13C-NMR.

The shape transition from spherical vibrator U(5) to -unstable deformed rotor O(6) in even-even Ru, Pd, and Xe isotopic chains are studied in framework of sd interacting boson model (IBM1) using the coherent state formalism to obtain the potential energy surfaces (PES’s). The location of critical points in the transition are identified by analysis the PES’s in terms of the deformation parameter and by using the catastrophe theory in terms of the two essential parameters . By using the most general IBM1 Hamiltonian in Casimir form with neglecting the U(5) and SU(3) quadratic Casimir operators and introducing only one control parameter the PES leads to the same energy surface as the Q-consistent IBM Hamiltonian at . For the studied isotopic chains, the -test is used to perform the fitting between the experimental and the corresponding calculated IBM for some selected energy levels and electric quadrupole …

Metaheuristic optimization algorithms present an effective method for solving several optimization problems from various types of applications and fields. Several metaheuristics and evolutionary optimization algorithms have been emerged recently in the literature and gained widespread attention, such as particle swarm optimization (PSO), whale optimization algorithm (WOA), grey wolf optimization algorithm (GWO), genetic algorithm (GA), and gravitational search algorithm (GSA). According to the literature, no one metaheuristic optimization algorithm can handle all present optimization problems. Hence novel optimization methodologies are still needed. The Al-Biruni earth radius (BER) search optimization algorithm is proposed in this paper. The proposed algorithm was motivated by the behavior of swarm members in achieving their global goals. The search space around local solutions to be explored is determined by Al-Biruni earth radius calculation method. A comparative analysis with existing state-of-the-art optimization algorithms corroborated the findings of BER’s validation and testing against seven mathematical optimization problems. The results show that BER can both explore and avoid local optima. BER has also been tested on an engineering design optimization problem. The results reveal that, in terms of performance and capability, BER outperforms the performance of state-of-the-art metaheuristic optimization algorithms.

A pot trial was conducted in the greenhouse of the National Research Centre, Dokki, Cairo, Egypt to study the effect of two levels of phosphorus P1 (1.44) and P2 (2.16) g P2O5 pot-1 and four Sulphur levels S0, S1, S2 and S3 at (0, 10, 15 and 20 g pot-1) on yield components of fababean, N and seed protein content as well as S-amino acid content (Methionine and Cysteine). The results showed that phosphorus and sulphur did not exhibit a significant effect on pod number however, seed number was decreased by P and S-treatments. Seed yield was increased at high P-level under S-levels, up to 15 g S pot-1, thereafter it declined. The best effect on both pod and seed weight was obtained by 10 and 15 g S pot-1 under the higher P-level. Further increase of S-addition (20 g pot-1) caused significant reductions in pod and seed yield to compare with those without S at higher P-level. The chemical composition of fababean revealed that N-concentrations generally increased by P and S additions, but crude protein content decreased with the highest application rate of S (20 g pot-1). S effects were more pronounced at the high P level than at the lower one. The maximum increase in Cysteine and Methionine contents due to S addition were respectively 17.6 and 24.6% expressed as % of dry matter and 11.11 and 27.8% expressed as )g/16 g N).The results showed a slight increase in phosphorus concentration by increasing S levels up to 15 g pot-1 at the two P levels .The beneficial effect was evident from the interaction between S and P indicating synergism of both nutrients which is explained by the individual responses to each element and it was …

Arginine (R)-glycine (G)-aspartate (D) (RGD)-containing oligopeptides are known to be very effective in increasing the biocompatibility and bioconnectivity of gold nanorods (AuNRs), where the conformation of the RGD peptide plays a critical role. In this work, Fourier-transform infrared (FTIR) and circular dichroism (CD) spectroscopies are used to characterize the secondary structure of a typical RGD peptide, namely, (RGD)4PGC, in its solvated state and the AuNRs’ surface-bound state (AuNRs@RGD) at neutral pH. It is shown that such a 15-mer RGD contains a β-turn on its C-terminus (residue DPGC), a short β-strand in the middle, and a random coil on its N-terminus (the RGD replica region). Upon its binding to AuNRs, a small portion of the β-strand is converted into a random coil, thus having a longer segment of random coil than its free form. Moreover, the steady-state conformational change is accompanied by …

In the present work, the acid dyes namely, eriochrome cyanine R (ECR) and 2-(4-Sulfo phenyl azo)-1,8 dihydroxy-3,6 naphthalene disulfonic acid, trisodium salt (SPADNS) were effectively adsorbed by Cu(II)-thiourea modified cotton fibers (Cu(II)/Tu-MC) complex. FTIR, SEM, XPS analysis, thermogravimetric analysis, and potentiometric titration were utilized for characterization. The impact of the fundamental adsorption parameters was systematically investigated. The results reveal that the adsorption of ECR and SPADNS acid dyes occurs via a metal-coordination mechanism. Furthermore, the adsorption process follows the 2nd order kinetic model and Langmuir model adsorption isotherm. The Cu(II)/Tu-MC shows high adsorption capacities of 0.27 and 0.22 mmol/g for ECR and SPADNS, respectively. These findings indicate that the cationization of cellulose fibers with metal ions is a promising and efficient strategy …

Hybrid nanofluids can provide better physical strength, thermal conductivity, and mechanical resistance in many thermodynamic systems than pure nanofluids. To establish the novel results, using superior types of hybrid nanoparticles like graphene oxide (GO) and iron oxide (Fe3O4) is the main focus of recent work. This study investigates the innovative thermal and magnetic features of both pure nanofluid GO/engine oil (EO) and hybrid nanofluid GO–Fe3O4 /EO under the simultaneous effects of induced as well as applied magnetic field. The chemical reaction phenomenon together with activation energy has also been taken into account. A novel algorithm based on order reduction and finite difference discretization is developed in order to numerically treat the problem. The efficiency of the code is appraised by a numerical comparison which is found to be in a good correlation with the existing …

This demonstration of study focalizes the melting transport and inclined magnetizing effect of cross fluid with infinite shear rate viscosity along the Skan-Falkner wedge. Transport of energy analysis is brought through the melting process and velocity distribution is numerically achieved under the influence of the inclined magnetic dipole effect. Moreover, this study brings out the numerical effect of the process of thermophoresis diffusion and Brownian motion. The infinite shear rate of viscosity model of cross fluid reveals the set of partial differential equations (PDEs). Similarity transformation of variables converts the PDEs system into nonlinear ordinary differential equations (ODEs). Furthermore, a numerical bvp4c process is imposed on these resultant ODEs for the pursuit of a numerical solution. From the debate, it is concluded that melting process cases boost the velocity of fluid and velocity ratio parameter …

Background: Pediatric onset Systemic lupus erythematosus (P-SLE) is an autoimmune multisystem illness with disease occurrence before the age of eighteen. It is a highly complicated condition with a significant variability across individuals. Aim of the study: To assess hematological parameters in P-SLE patients attending to the Pediatric Rheumatology out-patient clinic in Minia University Children Hospital, as well as, admitted to the in-patient ward and to evaluate the relationship between these hematological parameters and activity of P-SLE disease. Methods: This study was a prospective cross-sectional study included 40 children diagnosed with SLE attending to the Pediatric Rheumatology out-patient clinic in Minia University Children Hospital, as well as, admitted to the in-patient ward, from August 2020 to January 2022. Also, 40 apparently healthy children were included as a control group. They are age and sex matched, with the children having SLE. All enrolled Patients were subjected to: Detailed history taking, complete clinical examination, laboratory investigations including:  complete blood count (CBC)  Results: Both Patients with mild disease activity and Patients with moderate to high disease activity had significantly lower hemoglobin level than controls (P= 0.004 and 0.04 respectively), but there is non significant positive correlation between Hb level and SLEAI score as r = 0.382 and p = 0.142. Conclusion: Children having Systemic lupus erythematosus are more likely to have lower hemoglobin level than healthy children which may result in high morbidity in P-SLE, but lower hemoglobin level may not be closely associated with P …

Because of its multivariate particle suspension approach, the developing class of fluid has a better level of stability as well as increased heat transfer. In this regard, hybrid nanofluid outperforms ordinary fluid and even well-known nanofluid. In a slick environment, we investigate its fluidity and heat transfer qualities. Nano-leveled particle morphologies, porousness materials, variable thermal conductivity, slippage velocity, and thermal radiative effects are all being studied. The Galerkin finite element method is a numerical methodology for numerically solving the governing equations (G-FEM). For this analysis, a Powell-Eyring hybrid nanofluid (PEHNF) flowing via a permeable stretchable surface is used, which comprises two types of nanoparticles (NP), copper (Cu), and titanium alloy (Ti6Al4V) dispersed in sodium alginate (C6H9NaO7). The heat transfer ratio of PEHNF (Ti6Al4V-Cu/C6H9NaO7) remained much greater than that of conventional nanofluids (Cu-C6H9NaO7), with a range of 43%–54%. When lamina particles are present, the thermal conductivity of the boundary layer increases dramatically, while spherical nanoparticles have the lowest thermal conductivity. As nanoparticles are added under their fractional sizes, radiative heat conductance, and flexible heat conductance, the system’s entropy increases. The flow system’s ability to transport mass decreases when molecule diffusivity decreases dramatically. This is theoretically related to a rise in Schmidt number against molecular diffusivity.

Thiazolopyrimidines are designed to act as bio-isosteric analogues of purine nucleus. They proved to show a wide range of biological activities; such as anticancer, anti-inflammatory, antifungal, antiviral and antitubercular activity.In this study, a literature survey was performed to elect the most active thiazolopyrimidinecontaining scaffolds; acting as anticancer agents; to be subjected to extensive computational studies in order to explore the possible credible mode of their anticancer activity. First, drug-likeness was investigated for the most active derivatives, followed by molecular docking study against CDK, VEGFR and PI3K enzymes to assess their binding energy and propose the mode of action. Then, contact preference and surface mapping studies were carried out to explain the presence of remarkable affinity of certain analogues towards a specific enzyme, in addition to providing more information about their activity. Finally, physicochemical properties, Lipinski's rule and ADMET prediction studies were applied to predict the best route of administration and to suggest the pharmacokinetics of the most promising candidates.

Phase-change materials (PCMs) offer a compelling platform for active metaoptics, owing to their large index contrast and fast yet stable phase transition attributes. Despite recent advances in phase-change metasurfaces, a fully integrable solution that combines pronounced tuning measures, i.e., efficiency, dynamic range, speed, and power consumption, is still elusive. Here, we demonstrate an in situ electrically driven tunable metasurface by harnessing the full potential of a PCM alloy, Ge2Sb2Te5 (GST), to realize non-volatile, reversible, multilevel, fast, and remarkable optical modulation in the near-infrared spectral range. Such a reprogrammable platform presents a record eleven-fold change in the reflectance (absolute reflectance contrast reaching 80%), unprecedented quasi-continuous spectral tuning over 250 nm, and switching speed that can potentially reach a few kHz. Our scalable heterostructure …

Three series of new benzimidazole hybrids were designed and synthesized as promising human TopoII inhibitors. They were characterized by different spectroscopic techniques (1H, 13C NMR, ESI-MS and IR). All hybrids (6–23) were screened for their in vitro antiproliferative activity against five human cancer cell lines namely; HepG-2, MCF-7, PC-3, HCT-116 and Hela. Compound 21 showed the most potent anticancer activity against all cancer cell lines, with IC50 range of 2.82 to 12.59 µM, while proving safe towards normal cells WI-38 (IC50 = 31.89 µM) compared to the reference drug doxorubicin (IC50 = 6.72 µM). The most active candidates 13, 20, 21, 22 and 23 were further assessed for their human TopoII inhibition. The best of which, compounds 13 and 20 showed IC50 of 6.72 and 8.18 µM respectively compared to staurosporine (IC50 = 4.64 µM). Further mechanistic studies for compound 13 showed cell …

Targeted therapy has emerged to be the cornerstone of advanced cancer treatment, allowing for more selectivity and avoiding the common drug toxicity and resistance. Identification of potential targets having vital role in growth and survival of cancer cells got much easier with the aid of the recent advances in high throughput screening approaches. Various protein kinases came into focus as valuable targets in cancer therapy. Meanwhile, benzimidazole‐based scaffolds have gained significant attention as promising protein kinase inhibitors with high potency and varied selectivity. Great diversity of these scaffolds has inspired the medicinal chemists to inspect the effect of structural changes upon inhibitory activity on the molecular level through modeling studies. The present review gathers all the considerable attempts to develop benzimidazole‐based compounds; designed as protein kinase inhibitors with …

Introduction Sepsis is a life threatening condition which affects many children, Sepsis is said to be one of the leading causes of death among children even in advanced countries. Aim of the work toverify the association between cardiac dysfunction and serum ferritin level with unfavorable outcomes in pediatric sepsis. Patients and Methods This prospective cohort study was carried out on 40 patients with suspected or confirmed sepsis in our PICU. All patients in the study were subjected for assay of serum levels of ferritin, CRP and echocardiography on Day of admission & Day 3. Results Serum Ferritin level was significantly higher among cases with cardiac dysfunction than cases without cardiac dysfunction. There was highly statistically significant difference between day of admission D1 and third day as regard to serum ferritin level and CRP with median value of Ferritin level and CRP were higher on the day of admission compared to third day.

Based on modulation of the monastrol scaffold, two series of pyrimidinone derivatives, 3a–e and 5a–k, were designed, synthesized, and investigated for their in vitro anticancer activity. Compound 5j exhibited the most potent cytotoxic activity against four cancer cell lines, including HCT‐116, HeLa, HEPG‐2, and MCF‐7, with IC50 values of 3.75–5.13 µM, while proving to be safe in the normal human cell line WI‐38, with a selectivity index value of 13.7 on HCT‐116 cells. Compounds 3d, 3e, and 5h–j were further assessed for their Eg5 inhibitory activity, where 3d and 5h–j showed high Eg5 inhibition with IC50 values of 28.48, 24.22, 18.90, and 12.89 µM, respectively, when compared to monastrol (IC50 = 14.89 µM). Cell cycle distribution of HCT‐116 cells monitored with compound 5j illustrated that the cell cycle was arrested at the G2/M phase, with considerable apoptotic effect. A molecular docking study was …

Chemo-photothermal therapy has attracted extensive research attention because of its synergistic effect in destroying cancer cells, which makes it one of the most effective treatments. Gold nanorods conjugated with thiolated beta-cyclodextrin loaded with doxorubicin (DOX), AuNRs@S-β-CD-DOX nanocomposite, for intracellular delivery were designed to enhance therapeutic efficacy and improve toxicity of gold nanorods. The UV–vis absorption spectra of the AuNRs@S-β-CD nanocomposite showed strong absorption in the NIR region (biological window), making it a promising candidate for both photothermal therapy and chemotherapy. With such a combined chemo-photothermal effect, the viability of A549 lung cancer cells in vitro is anticipated to be significantly reduced making it a promising biomedical material for cancer treatment. The results show good photothermal efficiency of gold nanorods, high loading …

Background: Bell’s paralysis is an acute paralysis onset due to idiopathic facial nerve inflammation It is the commonest cause of lower motor neuron facial paralysis with an annual rate of 15-30 per 100,000.Objectives: Our aim of the study to detect the difference of axonal regeneration response in chronic Bell’s palsy to low intensity radial shock wave therapy and kabbat exercisesPatients and methods: 60 chronic bell’s palsy patients (six months post injury) with age 35-60 years old randomly allocated to one of two groups; group A [Shock Wave (SW)](n= 30) treated with low intensity shock wave plus kabbat exercises and facial muscle exercise for six weeks. KE (kabbat exercise) group (n= 30) treated with kabbat exercises plus sham treatment by a shock wave and facial muscle exercise for six weeks. patients were assessed by electrophysiological study (Amplitude and degeneration index of facial nerve). The assessment was done before and after treatment.Results: Degeneration index decrease significantly in the group A (p< 0.001), but not in the group B (p= 0.295). Amplitude of facial nerve was low at baseline, indicating sever axonal degeneration. After treatment, amplitude increased significantly in the two groups; however, the significance was higher in group A (SW) than group B (KE)(p< 0.001).Conclusion: low intensity shock wave therapy is safe and effective treatment of chronic bell’s palsy after 6 months from the onset.

Background Management of post burn alopecia has beenan obstacle to plastic surgeons nowadays, there is variablesurgical methods which makes it difficult to choose the suitabletreatment for each patient.Objective To assess the feasibility of platelet rich plasmause in hair transplantation in treatment of post burn scaralopecia to choose of the suitable treatment algorithm for thistype of deformity to obtain the highest possible patient satisfactionrate with the least-possible complication rate.Methods This prospective clinical study was conductedin Benha University Hospitals, Plastic and Burn SurgeryDepartment in the period between January 2021 and January2022. 20 patients with post burn alopecia were included inthe study. Patients were randomized using envelop methodinto two groups, where each group contains 10 patients asfollows: Group A: Patients received local intradermal PRPinjections one week before hair transplantation followed bytwo injections 2 and 4 weeks postoperatively. Group B (Controlgroup): Patients underwent hair transplantation only withoutany kind of local injections.Results Using this procedure is less invasive, less expensivewith less post-operative burden on the patients. However,it requires special skills for proper harvesting and insertingof follicular grafts. Operative time and number of sessionswere reasonable and convenient to the patients. Complicationswere quite mild and acceptable to the patients.Conclusion It was concluded that using PRP in FUE isuseful in treatment of post burn alopecia, hair transplantationhas less hazards during anesthesia, less post-operative complicationsand shorter recovery time …

In order to understand the characteristics of bio-convection and moving microorganisms in flows of magnetized Walters-B nano-liquid, we developed a model employing Riga plate with stretchy sheet. The Buongiorno phenomenon is likewise employed to describe nano-liquid motion in the Walters-B fluid. Expending correspondence transformations, the partial differential equation (PDE) control system has been transformed into an ordinary differential equation (ODE) control system. The COMSOL program is used to generate mathematical answers for non-linear equations by employing the Galerkin finite element strategy (G-FEM). Utilizing logical and graphical metrics, temperature, velocity, and microbe analysis are all studied. Various estimates of well-known physical features are taken into account while calculating nanoparticle concentrations. It is demonstrated that this model's computations directly relate the …

Combination nanodrugs are promising therapeutic agents for cancer treatment. However, they often require the use of complex nanovehicles for transportation into the tumor site. Herein, a new class of carrier-free ionic nanomaterials (INMs) is presented, which are self-assembled by the drug molecules themselves. In this regard, a photothermal therapy (PTT) mechanism is combined with a chemotherapy (chemo) mechanism using ionic liquid chemistry to develop a combination drug to deliver multiple cytotoxic mechanisms simultaneously. Nanodrugs were developed from an ionic material-based chemo-PTT combination drug by using a simple reprecipitation method. Detailed examination of the photophysical properties (absorption, fluorescence emission, quantum yield, radiative and non-radiative rate) of the INMs revealed significant spectral changes which are directly related to their therapeutic effect. The …

Efficient hybrid plasmonic-photonic metasurfaces that simultaneously take advantage of the potential of both pure metallic and all-dielectric nanoantennas are identified as an emerging technology in flat optics. Nevertheless, postfabrication tunable hybrid metasurfaces are still elusive. Here, we present a reconfigurable hybrid metasurface platform by incorporating the phase-change material Ge2Sb2Te5 (GST) into metal-dielectric meta-atoms for active and nonvolatile tuning of properties of light. We systematically design a reduced-dimension meta-atom, which selectively controls the hybrid plasmonic-photonic resonances of the metasurface via the dynamic change of optical constants of GST without compromising the scattering efficiency. As a proof-of-concept, we experimentally demonstrate two tunable metasurfaces that control the amplitude (with relative modulation depth as high as ≈80%) or phase (with …

Electrochemical nitrogen reduction reaction (NRR) for ammonia synthesis might offer an alternative means to the capital- and carbon-intensive thermochemical process (Haber-Bosch) in a clean, sustainable, and decentralized way if the process is coupled to renewable electricity sources. One of the challenges in electrochemical ammonia synthesis is finding catalysts with a suitable activity for breaking N2 triple bonds at or near ambient conditions. Improving the design of electrocatalysts, electrolytes, and electrochemical cells is required to overcome the selectivity and activity barrier in electrochemical NRR. In-situ and operando surface-enhanced Raman spectroscopy (SERS) is a well-suited technique to probe electrochemical reactions at the solid-liquid (electrode/electrolyte) interface. Operando SERS allows for the detection of intermediate species even in low abundance and is used to provide insights into NRR mechanisms using hybrid plasmonic nanostructures (e.g., Au-Pd) by combining spectroscopy and electrochemistry. A potentiostat is used to apply potential on a SERS active substrate that is then monitored by changes in a spectrum. The spectroelectrochemical cell is developed to operando probe the trace of NH3 and possible intermediate species produced at the electrode/electrolyte interface. This work would aid in understanding the reaction mechanism and ultimately designing more efficient catalysts for electrochemical energy conversion systems. This material is based upon work supported by the National Science Foundation under grant no. 1904351.

It is now well-accepted that nanoparticles (NPs) introduced into a biological environment will interact with the available proteins that deposit on their surface in a process known as protein corona (PC) formation which control NP interactions with cells and biological barriers. Several investigations have been conducted to understand the mechanisms and kinetics of PC formation. Among the model nanoprobes are gold (Au) NPs that possess unique optical and electromagnetic properties due to their surface plasmon resonance. These properties make Au NPs excellent probes for studying PC formation. In this Review, we describe techniques and approaches that a researcher interested in investigating PC on Au NPs may utilize in order to characterize the PC formation.

Utilizing solar energy for chemical transformations has attracted a growing interest in promoting the clean and modular chemical synthesis approach and addressing conventional thermocatalytic systems’ limitations. Photoelectrochemical (PEC) cells enabling the conversion of solar energy to storable and transportable fuels could address the existing challenge of mismatch between renewable energy supply and demand. Understanding the electronic and thermal properties of metal nanoparticles and their interactions with other materials is imperative to improve PEC cells’ efficiency. PECs typically consist of architecturally sophisticated photoelectrocatalysts assembled into a structure designed to optimize light harvesting and catalytic chemical transformations. Physical and chemical processes critical to PEC cells’ operation occur at the electrode-electrolyte interface. After plasmonic excitation of metal with …

Ammonia holds great promise as a carbon-neutral liquid fuel for storing intermittent renewable energy sources and power generation due to its high energy density and hydrogen content. Photo-Electrochemical Ammonia Synthesis: Nanocatalyst Discovery, Reactor Design, and Advanced Spectroscopy covers the synthesis of novel hybrid plasmonic nanomaterials and their application in photo-electrochemical systems to convert low energy molecules to high value-added molecules and looks specifically at photo-electrochemical nitrogen reduction reaction (NRR) for ammonia synthesis as an attractive alternative to the long-lasting thermochemical process. Provides an integrated scientific framework, combining materials chemistry, photo-electrochemistry, and spectroscopy to overcome the challenges associated with renewable energy storage and transport Reviews materials chemistry for the synthesis of a …

In Egypt, strawberry is an economically important crop that has recently been destroyed by Pentodon algerinum, a worldwide polyphagous destructive insect pest. This study aimed to distinguish, for the first time, the histopathological and morphological effects of Spodoptera littoralis Nuclear polyhedrosis virus (SpliNPV) and Pentodon algerinum Nuclear polyhedrosis virus (PNPV) on Pentodon algerinum third instar larvae to confirm their success as safe alternative control agents against this pest. The results showed that PNPV and SpliNPV affected Pentodon larvae by the same effects in causing the following: integument deformation and rupture; the destruction of the hypodermal layer resulting in the inhibition of the process of molting into the pupa stage, reducing pest survival; larva leg corrosion, which prevents its spreading; the rupture of fat bodies, which leads to the loss of stored energetic materials; the distortion of muscle sarcolemma and fibers resulting in weakness and softness; the tracheal cuticular layer destruction, which inhibits breathing; midgut rupture with cells detaching from each other; irregular cytoplasm distribution; the loss of the columnar shape of cells; the appearance of vacuoles between cells, which results in their inability to feed or to digest; the swelling, softness, liquefaction, and, lastly, death of the larva.

This study aims mainly to identify the role of green technology in achieving the competitive advantage of the public business sector by providing a scientific and practical framework on the concept of green technology for the companies under study. In terms of identifying the nature of green technology, its objectives, its advantages, and its role in achieving Competitive advantage by preparing a questionnaire list and using Pearson correlation coefficients and simple regression model to study the impact of the independent variable, which is green technology, on the dependent variable, which is the competitive advantage by addressing addressing the dimensions of competitive advantage, namely (Quality – Innovation and creativity). The study sample was represented by 20 public business sector companies under study, by by collecting 308 returned and valid forms for statistical analysis. The study concluded that there is a major role for green technology on the dimensions of competitive advantage in the public business sector under study. The researchers recommended the need to adopt the application of green technology and disseminate it to all public business sector companies, in order to benefit from the advantages of its application, in addition to the importance of raising the cultural awareness of technology among company employees. And trying to take care of the public business sector companies by providing the material or moral support necessary for the transition to green technology in a way that helps improve their competitive position.

Foundation: Lower urinary plot side effects (LUTS) related with benevolent prostatic hyperplasia (BPH) and erectile brokenness (ED) are basic problems whose pervasiveness increments with propelling age We expected to think about between viability of tadalafil 5 mg and tamsulosin 0.4mg monotherapy versus joined treatment in treatment of lower urinary parcel indications of generous prostatic hyperplasia. Patient and techniques: This randomized, single-daze, resembled bunch clinical preliminary was done on 60 patients with ED and LUTS because of BPH were remembered for an imminent report and Received treatment. Gathering A got 5 mg/day by day tadalafil; Group B got 0.4 mg/day by day tamsulosin; Group C receieved a blend of 0.4 mg/day by day tamsulosin and 5 mg/day by day tadalafil.          The three gatherings were been contrasted concurring with International prostate indication score (IPSS), International file of erectile brokenness (IIEF) score and maximal urinary stream rate (Qmax) Results: Post-void remaining level was essentially extraordinary when the treatment, aside from bunch A. Additionally, this gathering had no significant distinction contrasted with different gatherings in such manner (P > 0.05). There were huge contrasts among pre-and post-treatment global prostate side effect scores in each gathering (P < 0.05). End: blend treatment with tadalafil and tamsu-losin is suggested as a result of its great results in erectile brokenness.

Nanoscale diagnostic and therapeutic agents have been in use since the development of micellar nanocarriers and polymer-drug nanoconjugates in the mid-1950s, liposomes by Bangham and Watkins in the mid-1960s, and the introduction of polymeric nanoparticles by Langer and Folkman in 1976. Since then, nanoscale constructs such as dendrimers, protein nanoconjugates, and inorganic nanoparticles have been developed for the systemic delivery of agents to specific disease sites. This chapter explores the emerging applications of noble metal nanotechnologies in cancer diagnostics and therapeutics carried out by our group. In a more recent, but related, study investigating cellular effects from glycine-aspartic acid/nuclear localization sequence silver nanoparticles, the authors' group observed that apoptotic induction in malignant cells by these particles led to the attraction of neighboring cells and their …

A temporal change in acidity on the titania surface during UV irradiation was indirectly monitored by evaluating the deposited fluorescein dye using surface plasmon resonance spectroscopy such that gold nanoparticles were embedded under the titania thin film in order to increase the sensitivity. The fluorescence signal mainly originated from the highly fluorescent dianion species of fluorescein in the fluorescence time profiles after the femtosecond laser excitation. The signal monotonously decayed with a single exponential function on silica, whereas the signal rose and decayed with a double exponential function on the titania. The present femtosecond time-resolved fluorescence study revealed that a process involving the transformation from the monoanion to dianion of fluorescein “in the excited states”, i.e., the excited state proton transfer from the dye molecule to the titania surface, induced the subsequent …

The present work is devoted to studying the possibilities of laser etching of TiS3 nanorib-bons using Raman spectroscopy. The main parameters considered in this study are laser power and exposure time.

A novel selective nano-chitosan liquid membrane sensor depends on the combination between chitosan and 2-(5-Bromo-2-Pyridylazo)-5-[N-n-Propyl-N-(3-sulfopropyl)amino]aniline reagent was success-fully developed. The characteristics slope (54 mV/decade),linear range response from 1.0×10−7-1.0×10−2 M, limit of detection(1.47 × 10-8) M, selectivity study toward some inorganic cations, the time of response(10s), lifespan (five months), pH influence on the electrode potential and the crucial characteristic factors were studied. The electrode was successfully employed to estimate nano-chitosan in food supplements and fruit juice with nano-chitosan. The results obtained by the nominated sensor were analyzed, statistically treated and compared with the other recently described sensors.

2021-03-29 Assigned to GEORGIA TECH RESEARCH CORPORATION reassignment GEORGIA TECH RESEARCH CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EL-SAYED, MOSTAFA A., Ali, Moustafa RK

The pandemic COVID-19 caused by SARS-CoV-2 has continued, and it is here to stay for longer. It has already resulted in 41 570 883 confirmed cases of COVID-19, including 1 134 940 deaths, as reported by the WHO and the Center for Systems and Engineering (CSSE) at Johns Hopkins University (JHU). The numbers are rising and increasing rapidly according to both organizations. https://covid19. who. int; https://coronavirus. jhu. edu/map. htmlThe global effect on all health care service provider disciplines and practice has been severe and immense, and they have been strongly hit hard. This crisis has led to redirection of surgical resources of all types, including surgeons, anesthetists, trainees, nurses, equipment, operating theaters, and recovery rooms [1–3].

We designed novel biocompatible nanocomposite composed of gold nanorods coated with rod-like mesoporous silica SBA-15-SH particles, (GNRs@SBA-15-SH) as a new synergistic therapeutic device to deliver heat and drug to cancer cells for tumor eradication. For this purpose, doxorubicin (DOX) was loaded into GNRs@SBA-15-SH nanocomposites and studied their photothermal therapy, chemotherapy and the combined effect on the ablation of A549 cells in vitro using human lung cancer cells, A549. The results demonstrate the high photothermal efficacy of gold nanorods loaded into the nanocomposite, the thermo-responsive properties of GNRs@SBA-15-SH, the high loading capacity of DOX into the GNRs@SBA-15-SH and its biocompatibility. Synergistic chemo-photothermal of the GNRs@SBA-15-SH/DOX nanocomposite in the eradication of cancer cells under laser irradiation (808 nm), demonstrates the …

Background Placenta accreta is becoming an increasingly common complication of pregnancy. Placenta accreta originates from abnormal trophoblast invasion.  Objective to assess if uterine artery Doppler and Placental Morphological Features could be predictors of maternal and fetal outcome in pregnancies complicated with placenta previa and placenta previa accreta. Subjects and methods This study included 80 pregnant women of which they were divided into 3 groups. The first group included 40 pregnant women of normal pregnancies, 2nd one included 20 pregnant women with placenta previa and the 3rd one included 20 pregnant women with suspected placenta previa accreta by ultrasound. Abdominal ultrasound and uterine artery Doppler were done in a week before delivery.  Results There was a direct relationship between presence of lacunae especially high grade, placental vascularity (abnormal) and the mean values of uterine artery PI, RI and presence of peripartum maternal and fetal complications.  Conclusion the gray scale and color Doppler ultrasound have a high diagnostic value in the diagnosis by certain placental morphological features, Including loss of retro-placetal clear zone, thinning of myometrial thickness, Intraplacental lacunae, Intraplacental vascularity and exophytic mass into bladder space. Ultrasound is helpful and non-invasive tool in prediction of maternal and fetal outcome. High grade of placental lacunae and abnormal placental vascularity were highly associated with maternal and fetal complications. Uterine artery Doppler PI and RI is also useful in prediction of maternal complications and fetal …

Utilizing solar energy for chemical transformations has attracted a growing interest in promoting the clean and modular chemical synthesis approach and addressing the limitations of conventional thermocatalytic systems. Under light irradiation, noble metal nanoparticles, particularly those characterized by localized surface plasmon resonance, commonly known as plasmonic nanoparticles, generate a strong electromagnetic field, excited hot carriers, and photothermal heating. Plasmonic nanoparticles enabling efficient absorption of light in the visible range have moderate catalytic activities. However, the catalytic performance of a plasmonic nanoparticle can be significantly enhanced by incorporating a highly catalytically active metal domain onto its surface. In this study, we demonstrate that femtosecond laser-induced atomic redistribution of metal domains in bimetallic Au–Pd nanorods (NRs) can enhance its …

AbstractMulti-core processors have become widespread computing engines for recent embedded real-time systems. Efficient task partitioning plays a significant role in real-time computing for achieving higher performance alongside sustaining system correctness and predictability and meeting all hard deadlines. This paper deals with the problem of energy-aware static partitioning of periodic, dependent real-time tasks on a homogenous multi-core platform. Concurrent access of the tasks to shared resources by multiple tasks running on different cores induced a higher blocking time, which increases the worst-case execution time (WCET) of tasks and can cause missing the hard deadlines, consequently resulting in system failure. The proposed blocking-aware-based partitioning (BABP) algorithm aims to reduce the overall energy consumption while avoiding deadline violations. Compared to existing partitioning strategies, the proposed technique achieves more energy-saving. A series of experiments test the capabilities of the suggested algorithm compared to popular heuristics partitioning algorithms. A comparison was made between the most used bin-packing algorithms and the proposed algorithm in terms of energy consumption and system schedulability. Experimental results demonstrate that the designed algorithm outperforms the Worst Fit Decreasing (WFD), Best Fit Decreasing (BFD), and Similarity-Based Partitioning (SBP) algorithms of bin-packing algorithms, reduces the energy consumption of the overall system, and improves schedulability.

A newly fabricated chromium selective liquid electrode sensor was successfully designed according to the reaction between nano-chitosan and chromium(III) ions. The characteristics specific slope ( 58.5 mV/decade), linearity range of concentration from 1.0x10-6-1.0x10-1 M, the limit of detection (1.32×10-8)M, selectivity behavior among some inorganic cations, the dynamic response time(10s), lifespan (four months),the potential dependence on pH and basic interesting validations and parameters were investigated. The nominated electrode was successfully utilized to detect chromium(III) ions in pharmaceutical and foodstuff samples. The data provided by the developed sensor were treated, statistically and compared with other electrodes listed in the literature.

Nucleic acid therapeutics hold an unprecedented promise toward treating many challenging diseases; however, their use is hampered by delivery issues. Microfluidics, dealing with fluids in the microscale dimensions, have provided a robust means to screening raw materials for development of nano delivery vectors, in addition to controlling their size and minimizing their polydispersity. In this mini-review, we are briefly highlighting the different types of nucleic acid therapies with emphasis on the delivery requirement for each type. We provide a thorough review of available methods for the development of nanoparticles, especially lipid nanoparticles (LNPs) that resulted in FDA approval of the first ever nucleic acid nanomedicine. We then focus on recent research attempts for how microfluidic synthesis of lipid nanoparticles and discuss the various parameters required for successful formulation of LPNs including chip …

The anal pressure abnormalities in haemorrhiods before and after surgery were studied by an ano-rectal manometric technique. Fifty consecutive patients (32 men, 18 women; mean age 42.96 years) with symptomatic haemorrhoids (grades III and IV) and different degrees of severity were submitted to this study. Schedule excisional haemorrhoidectomy might have been performed. Those butt-centric resting weight were monitored previously, then at then afterward two months for surgery when those wounds required mended. There might have been critical diminishing in the mean resting weight "around instances post-operative over pre-operative. Sodergren haemorrhoid manifestation seriousness scoring framework were used to quantify those seriousness about haemorrhoidal symptoms, as stated by this scoring framework there were no huge Contrast between Different degrees for seriousness in regards should manometrical effects (resting butt-centric pressure).

BackgroundPathogens stimulate presepsin (P-SEP) shedding from immune cells such as macrophages, monocytes, and neutrophils. Although its function is still unclear, P-SEP is believed to interact with B and T cells to modulate specific immune responses. We aimed to evaluate the accuracy of P-SEP as a novel biomarker for the diagnosis of bacterial infection and correlate its level with blood culture, C-reactive protein (CRP), and procalcitonin (PCT) levels.Materials and Methods: This is a prospective comparative study conducted at Minia University Hospital, Egypt, including eighty neonates. They were divided into two groups: Group I: Twenty full term neonates; infants> 37 weeks. Group II: Sixty preterm neonates< 37 weeks, it was classified into three subgroups; Group II A: 20 Low birth weight neonates: 1501-2500 gr, Group II B: 20 Very low birth weight neonates: 1001-1500 gr, Group II C: 20 Extremely low birth weight neonates: 500-1000 gr. Cord presepsin (presepsin 1) was measured at birth. CBC, CRP, Blood culture, Procalcitonin and presepsin 2 were measured after the onset of sepsis.Results: No significant difference in levels of P-SEP 1 was found between the two groups. P-SEP 2 levels were higher in sepsis group than in non-sepsis group. Presepsin showed more diagnostic accuracy than PCT in diagnosis of sepsis. The best cut-off value for Presepsin was 485 pg/ml, with 97.8% sensitivity, and 94.1% specificity.

ConspectusAs renewable energy sources are either intermittent in nature or remote in location, developing cost-effective, sustainable, modular systems and technologies to store and transport renewables at an industrial scale is imperative. Storing cheap renewable electricity into chemical bonds (i.e., chemical energy storage) could be a transformative opportunity for reliable and resilient grid energy storage. This approach enables renewables to be stored and shipped similarly to fossil fuels. Currently, the chemical industry primarily consumes fossil feedstock as an energy source, which has been the standard for over a century. A paradigm shift is required to move toward a more sustainable route for chemical synthesis by electrifying and decarbonizing the modern chemical industry. As renewable electricity costs decrease, (photo)electrosynthesis is gaining interest for synthesizing high-value and high-energy fuels …

Lung failure is the main reason for mortality in COVID-19 patients, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, no drug has been clinically approved for treatment of COVID-19. Nanotechnology has a great potential in contributing significantly to the fight against COVID-19 by developing effective therapies that can selectively eradicate the respiratory virus load. We propose a novel COVID-19 management approach that is efficient in eliminating the virus load from the airways and protecting the lungs from the fatal effects of the virus. This approach relies on targeting the virus using ACE-2-functionalized gold nanorods (AuNRs) followed by irradiation with near-infrared (NIR) light for the selective eradication of SARS-CoV-2 without off-target effects, i.e., targeted plasmonic photothermal therapy. Using discrete dipole approximation (DDA), we quantitatively determined …

Objective of the Study The objective of this study was to determine the effect of storage times and temperatures on the physicochemical, microbial and textural properties of UHT-processed cheese.

The goal of the project is on understanding the principles of non-covalent assembling of tunable functional materials with various nanocrystals in order to control light-matter interactions by changing localized interfacial refractive properties, coupling parameters, or the ionic environment of surrounding media. We explore novel soft functional matrices with controlled physical properties via the application of light, mechanical stresses, ionic environment, and electrical potential. These functional matrices is used in conjunction with novel anisotropic inorganic nanostructures such as noble metal/metal alloy anisotropic nanostructures with complex optical properties (multiple LSPR modes) and quantum dots with light-emissive or absorbing properties in a broad spectral range from the UV to the NIR for efficient solar energy absorption and light conversion.

Three new series of phenyl dihydropyridazinone derivatives 4b–8i have been designed, synthesized and evaluated for their anticancer activity against different cancer cell lines. Nine compounds showed strong inhibitory activity, among which compound 8b exhibited potent activity against PC-3 cell line with IC50 value of 7.83 µM in comparison to sorafenib (IC50 11.53 µM). Compounds 6a, 6c, 7f-h and 8a-d were further screened for their B-Raf inhibitory activity where seven compounds 7f-h and 8a-d showed high B-Raf inhibition with ranges of IC50 values 70.65–84.14 nM and 24.97–44.60 nM, respectively when compared to sorafenib (IC50 44.05 nM). Among the tested compounds, 8b was the most potent B-Raf inhibitor with IC50 value of 24.79 nM. Cell cycle analysis of MCF-7 cells treated with 8b showed cell cycle arrest at G2-M phase with significant apoptotic effect. Molecular modeling study was performed to …

In this work, 21 novel (1,4-disubstituted 1,2,3-triazole)-dihydropyrimidinone (1,2,3-trzl-DHPM) type hybrids were synthesized and characterized. These were divided into two types: hybrids A (5 in total) containing the dihydropyrimidinone heterocyclic ring decorated with a 1,4-disubstituted 1,2,3-triazole in the C-5 position [these compounds were accessed by a multicomponent copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) (or click)–Biginelli reactions with satisfactory yields (39–57%)] and hybrids B (16 in total) containing two 1,2,3-triazole units in the C-5 and C-6 methyl position of the DHPM. Hybrids B were synthesized via functionalization of the C-6 methyl group of hybrids A, a multistep sequence of reactions was used that included bromination, azidation, and a CuAAC. Hybrids B were obtained in very good to excellent yields (up to 99%). Some hybrids A and B were evaluated for their antiproliferative …

We omitted a proper citation and copyright statement to Figure 1a, e. Thus, the following sentence should be added to the Figure 1 caption:“Panels a and e of Figure 1 are adapted from our previously published article in ref 62 (doi. org/10.1021/jacs. 6b08787). Copyright 2016 American Chemical Society.” This happened because the same batches of gold nanoparticles were used in both articles. The correction doesn’t affect any article results, discussions, or conclusions. It is worth noting that this was an unintentional error.

Интеллектуальное здравоохранение представляет большой интерес для исследователей и правительств в связи с растущим развитием новых умных городов. Однако в настоящее время отсутствует стандартная практика формирования эффективной вычислительной инфраструктуры и оказания помощи архитектору системы здравоохранения в разработке комплексного решения для основных услуг, необходимых пользователям здравоохранения. В данной статье рассматривается потенциальная роль облачных, мобильных технологий и технологий искусственного интеллекта в интеллектуальных медицинских услугах. Кроме того, возможности и технологические вызовы также обсуждаются с точки зрения информатики

The nuclear superdeformed bands in A∼ 190, A∼ 130 mass regions have been systematically analyzed by using the perturbed SU (3) limit of the interacting boson model. The g-bosons have been taken into consideration and the SU (3) symmetry is perturbed by introducing an interaction holding the SO (5) symmetry. A four parameters simple analytic formula for the eigenvalue equation has been derived. The spin determines of the studied superdeformed (SD) bands are considered from our previous works. The improved model parameters for each nucleus have been determined by operating a computer simulated search program so as to obtain a minimum root mean square divergence of the evaluating gamma ray transition energies and the observed ones. With these adopted model parameters the transition energies Eγ, the rotational frequencies ħω, the kinematic J (1) and dynamic J (2) moments of inertia have calculated and are in accordance with experimental data. The behavior of J (1) and J (2) as a function of ħω have been studied. The calculated Eγ have been used to investigate the anomalous∆ I= 2 staggering by considering the five point formula of Cederwall staggering parameter which represent the finite deviation calculation to the fourth order derivative of the transition energies at a determined spin.

Cost-effective production of ammonia via electrochemical nitrogen reduction reaction (NRR) hinges on N2 electrolysis at high current densities with suitable selectivity and activity. Here, we report our findings in electrochemical NRR for ammonia synthesis using porous bimetallic Pd–Ag nanocatalysts in both gas-phase and liquid-phase electrochemical cells at current densities above 1 mA cm–2 under ambient conditions. While the gas-phase cell has lower Ohmic losses and higher energy efficiency, the liquid-phase cell achieved higher selectivity and Faradaic efficiency, attributed to the presence of concentrated N2 molecules dissolved in an aqueous electrolyte and the hydration effects. The liquid cell demonstrated notable performance for electrocatalytic NRR, achieving an NH3 production rate of 45.6 ± 3.7 μg cm–2 h–1 at a cell voltage of −0.6 V (vs RHE) and current density of 1.1 mA cm–2, corresponding to a …

BackgroundGold nanoparticles (AuNPs) with unique physicochemical properties have received a great deal of interest in the field of biological, chemical and biomedical implementations. Despite the widespread use of AuNPs in chemical and biological sensing, catalysis, imaging and diagnosis, and more recently in therapy, no comprehensive summary has been provided to explain how AuNPs could aid in developing improved sensing and catalysts systems as well as medical settings.Scope of reviewThe chemistry of Au-based nanosystems was followed by reviewing different applications of Au nanomaterials in biological and chemical sensing, catalysis, imaging and diagnosis by a number of approaches, and finally synergistic combination therapy of different cancers. Afterwards, the clinical impacts of AuNPs, future application of AuNPs, and opportunities and challenges of AuNPs application were also …

Electrosynthesis of ammonia using nitrogen and water provides a potential alternative to the thermochemical process (Haber-Bosch) in a clean, sustainable, and decentralized way when electricity is generated from renewable sources. To enable the widespread commercialization of this technology, an electrocatalyst to convert nitrogen (N 2) to ammonia (NH 3) with high selectivity and activity must be developed. Here, we report our findings in the investigation into the role of incorporating palladium (Pd) in bimetallic Au-Ag nanocages on the electrocatalytic activity of the nitrogen reduction reaction (NRR) under ambient conditions. The localized surface plasmon resonance (LSPR) peak position of the resulting trimetallic nanoparticles is tuned with Pd concentration, achieving the highest electrocatalytic NRR activity (NH 3 yield rate= 5.80 μg cm− 2 h− 1, Faradaic efficiency= 48.94%) using Au-Ag-Pd-850 …

Development of optical nanobiosensors has emerged as one of the most important bioresearch areas of interest over the past decades especially in the modern innovations in the design and utilization of sensing platforms. The application of nanobiosensors has been accelerated with the introduction of plasmonic NPs, which overcome the most of the limitations in the case of conventional optical nanobiosensors. Since the plasmonic AuNPs-based nanobiosensors provide high potential achievements to develop promising platforms in fully integrated multiplex assays, some well-developed investigations are clearly required to improve the current technologies and integration of multiple signal inputs. Therefore, in this literature, we summarized the performance and achievements of optical nanobiosensors according to plasmonic rules of AuNPs, including SPR, LSPR, SERS and chiroptical phenomena. Also, we …

The photocatalyst titania film surface acquires a high hydrophilicity after it is exposed to UV light, which is induced by changes in the densities of the surface hydroxyl groups and charge. A xanthene dye, fluorescein, was deposited from a solution onto a titania film after UV irradiation in order to probe the titania surface change. The change in the surface acidity was confirmed by the ratio of dianion to monoanion of fluorescein by Raman spectroscopy. The ratio increased by UV irradiation, indicating that the surface became more basic. Transient absorption spectroscopy revealed the transformation from the monoanion to dianion via the excited states, that is, photoinduced proton transfer from fluorescein to the titania surface. The UV irradiation increases the basic hydroxyl groups on the titania surface, which accepts protons from the water molecules or proton donors on the surface and has a positive charge.

The shape transition between the vibrational U(5) and deformed -unstable O(6) dynamical symmetries of sd interacting boson model has been investigated by considering a modified O(6) Hamiltonian, providing that the coefficients of the Casimir operator of O(5) are N-dependent, where N is the total number of bosons. The modified O(6) Hamiltonian does not contain the number operator of the d boson, which is responsible for the vibrational motions. In addition, the deformation features can be achieved without using the SU(3) limit by adding to the O(6) dynamical symmetry the three-body interaction , where Q is the O(6) symmetric quadrupole operator. Moreover, triaxiality can be generated through the inclusion of the cubic d-boson interaction . The classical limit of the potential energy surface (PES), which represents the expected value of the total Hamiltonian in a coherent state, is studied …

Cost-effective production of ammonia via (photo)electrochemical nitrogen reduction reaction (NRR) hinges on N2 electrolysis at high current densities with suitable selectivity and activity [1, 2]. In this talk, we report our findings in electrochemical NRR for ammonia synthesis using porous bimetallic Pd-Ag nanocatalysts in both gas-phase and liquid-phase electrochemical cells at current densities above 1 mA cm-2 under ambient conditions. While the gas-phase cell has lower Ohmic losses and higher energy efficiency, the liquid-phase cell achieved higher selectivity and Faradaic efficiency, attributed to the presence of concentrated N2 molecules dissolved in an aqueous electrolyte and the hydration effects. The liquid cell demonstrated notable performance for electrocatalytic NRR, achieving an NH3 production rate of 45.6 µg cm-2 h-1 at a cathodic potential of -0.6 V (vs. RHE) and current density of 1.1 mA cm-2 …