Wang, Michael Y

University of Michigan-Dearborn

H-index: 150

North America-United States

Description

Wang, Michael Y, With an exceptional h-index of 150 and a recent h-index of 106 (since 2020), a distinguished researcher at University of Michigan-Dearborn, specializes in the field of Neurosurgery.

His recent articles reflect a diverse array of research interests and contributions to the field:

Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors

KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma

A measurement of the Higgs boson mass in the diphoton decay channel

Professor Information

University	University of Michigan-Dearborn
Position	___
Citations(all)	98904
Citations(since 2020)	51082
Cited By	32570
hIndex(all)	150
hIndex(since 2020)	106
i10Index(all)	1061
i10Index(since 2020)	750
Email	Access Email
University Profile Page	University of Michigan-Dearborn

Research & Interests List

Neurosurgery

Top articles of Wang, Michael Y

Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors

Background Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers. However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is complex. Natural killer (NK) cells that have been modified to express an anti-CD19 CAR have the potential to overcome these limitations. Methods In this phase 1 and 2 trial, we administered HLA-mismatched anti-CD19 CAR-NK cells derived from cord blood to 11 patients with relapsed or refractory CD19-positive cancers (non-Hodgkin’s lymphoma or chronic lymphocytic leukemia [CLL]). NK cells were transduced with a retroviral vector expressing genes that encode anti-CD19 CAR, interleukin-15, and inducible caspase 9 as a safety switch. The cells were expanded ex vivo and administered in a single infusion at one of three doses (1×105, 1×106, or 1×107 CAR-NK cells per kilogram of body …

Authors

Enli Liu,David Marin,Pinaki Banerjee,Homer A Macapinlac,Philip Thompson,Rafet Basar,Lucila Nassif Kerbauy,Bethany Overman,Peter Thall,Mecit Kaplan,Vandana Nandivada,Indresh Kaur,Ana Nunez Cortes,Kai Cao,May Daher,Chitra Hosing,Evan N Cohen,Partow Kebriaei,Rohtesh Mehta,Sattva Neelapu,Yago Nieto,Michael Wang,William Wierda,Michael Keating,Richard Champlin,Elizabeth J Shpall,Katayoun Rezvani

Journal

New England Journal of Medicine

Published Date

2020/2/6

KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma

Background Patients with relapsed or refractory mantle-cell lymphoma who have disease progression during or after the receipt of Bruton’s tyrosine kinase (BTK) inhibitor therapy have a poor prognosis. KTE-X19, an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, may have benefit in patients with relapsed or refractory mantle-cell lymphoma. Methods In a multicenter, phase 2 trial, we evaluated KTE-X19 in patients with relapsed or refractory mantle-cell lymphoma. Patients had disease that had relapsed or was refractory after the receipt of up to five previous therapies; all patients had to have received BTK inhibitor therapy previously. Patients underwent leukapheresis and optional bridging therapy, followed by conditioning chemotherapy and a single infusion of KTE-X19 at a dose of 2×106 CAR T cells per kilogram of body weight. The primary end point was the percentage of patients with an objective …

Authors

Michael Wang,Javier Munoz,Andre Goy,Frederick L Locke,Caron A Jacobson,Brian T Hill,John M Timmerman,Houston Holmes,Samantha Jaglowski,Ian W Flinn,Peter A McSweeney,David B Miklos,John M Pagel,Marie-Jose Kersten,Noel Milpied,Henry Fung,Max S Topp,Roch Houot,Amer Beitinjaneh,Weimin Peng,Lianqing Zheng,John M Rossi,Rajul K Jain,Arati V Rao,Patrick M Reagan

Journal

New England journal of medicine

Published Date

2020/4/2

A measurement of the Higgs boson mass in the diphoton decay channel

A measurement of the mass of the Higgs boson in the diphoton decay channel is presented. This analysis is based on 35.9 fb− 1 of proton-proton collision data collected during the 2016 LHC running period, with the CMS detector at a centre-of-mass energy of 13 TeV. A refined detector calibration and new analysis techniques have been used to improve the precision of this measurement. The Higgs boson mass is measured to be m H= 125.78±0.26 GeV. This is combined with a measurement of m H already performed in the H→ ZZ→ 4 ℓ decay channel using the same data set, giving m H= 125.46±0.16 GeV. This result, when further combined with an earlier measurement of m H using data collected in 2011 and 2012 with the CMS detector, gives a value for the Higgs boson mass of m H= 125.38±0.14 GeV. This is currently the most precise measurement of the mass of the Higgs boson.

Authors

Albert M Sirunyan,Armen Tumasyan,Wolfgang Adam,Federico Ambrogi,Thomas Bergauer,Marko Dragicevic,Janos Erö,A Escalante Del Valle,Martin Flechl,Rudolf Fruehwirth,Manfred Jeitler,Natascha Krammer,Ilse Krätschmer,Dietrich Liko,Thomas Madlener,Ivan Mikulec,Navid Rad,Jochen Schieck,Robert Schöfbeck,Markus Spanring,Wolfgang Waltenberger,C-E Wulz,Mateusz Zarucki,Vladimir Drugakov,J Suarez Gonzalez,MR Darwish,EA De Wolf,D Di Croce,X Janssen,A Lelek,M Pieters,H Rejeb Sfar,H Van Haevermaet,P Van Mechelen,S Van Putte,F Blekman,ES Bols,SS Chhibra,J D'Hondt,J De Clercq,D Lontkovskyi,S Lowette,I Marchesini,S Moortgat,Q Python,S Tavernier,W Van Doninck,P Van Mulders,D Beghin,B Bilin,B Clerbaux,G De Lentdecker,H Delannoy,B Dorney,L Favart,A Grebenyuk,AK Kalsi,L Moureaux,A Popov,N Postiau,E Starling,L Thomas,C Vander Velde,P Vanlaer,D Vannerom,T Cornelis,D Dobur,I Khvastunov,M Niedziela,C Roskas,K Skovpen,M Tytgat,W Verbeke,B Vermassen,M Vit,O Bondu,G Bruno,C Caputo,P David,C Delaere,M Delcourt,A Giammanco,V Lemaitre,J Prisciandaro,A Saggio,M Vidal Marono,P Vischia,J Zobec,GA Alves,G Correia Silva,C Hensel,A Moraes,E Belchior Batista Das Chagas,W Carvalho,J Chinellato,E Coelho,EM Da Costa,GG Da Silveira,D De Jesus Damiao,C De Oliveira Martins,S Fonseca De Souza,LM Huertas Guativa,H Malbouisson,J Martins,D Matos Figueiredo,M Medina Jaime,M Melo De Almeida,C Mora Herrera,L Mundim,H Nogima,WL Prado Da Silva,P Rebello Teles,LJ Sanchez Rosas,A Santoro,A Sznajder,M Thiel,EJ Tonelli Manganote,F Torres Da Silva De Araujo,A Vilela Pereira,CA Bernardes,L Calligaris,TR Fernandez Perez Tomei,EM Gregores,DS Lemos,PG Mercadante,SF Novaes,Sandra S Padula,A Aleksandrov,G Antchev,R Hadjiiska,P Iaydjiev,M Misheva,M Rodozov,M Shopova,G Sultanov,M Bonchev,A Dimitrov,T Ivanov,L Litov,B Pavlov,P Petkov,A Petrov,W Fang,X Gao,L Yuan,M Ahmad,Z Hu,Y Wang,GM Chen,HS Chen

Journal

Physics Letters B

Published Date

2020/6/10