Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation
Chinese medical journal
Published On 2024/1/20
Background Oral anti-coagulants (OAC) are the intervention for the prevention of stroke, which consistently improve clinical outcomes and survival among patients with atrial fibrillation (AF). The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in China. Methods Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation (CCC-AF) registry, guideline-recommended OAC use in eligible patients was assessed. Results A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019, of whom 38,203 were at a high risk of stroke, 9717 were at a moderate risk, and 4610 were at a low risk. On admission, only 20.0% (6075/30,420) of patients with a diagnosed AF and a high risk of stroke were taking OAC. The use of pre-hospital OAC on admission was associated with a lower risk of new-onset …
Journal
Chinese medical journal
Volume
137
Issue
2
Page
172-180
Authors
Gregg C. Fonarow
University of California, Los Angeles
H-Index
206
Research Interests
Cardiololgy
heart failure
quality of care and outcomes
University Profile Page
Other Articles from authors
Gregg C. Fonarow
University of California, Los Angeles
Applied Clinical Informatics
Patients with Heart Failure: Internet Use and Mobile Health Perceptions
Background Heart failure is a complex clinical syndrome noted on approximately 1 in 8 death certificates in the United States. Vital to reducing complications of heart failure and preventing hospital readmissions is adherence to heart failure self-care routines. Mobile health offers promising opportunities for enhancing self-care behaviors by facilitating tracking and timely reminders. Objective We sought to investigate three characteristics of heart failure patients with respect to their heart failure self-care behaviors: (1) internet use to search for heart failure information; (2) familiarity with mobile health apps and devices; and (3) perceptions of using activity trackers or smartwatches to aid in their heart failure self-care. Methods Forty-nine heart failure patients were asked about their internet and mobile health usage. The structured interview included questions adapted from the Health Information National Trends Survey …
2024/2/21
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Heart Rhythm O2
Outcomes with guideline-directed medical therapy and cardiac implantable electronic device therapies for patients with heart failure with reduced ejection fraction
BackgroundLimited real-world evidence exists for outcomes with contemporary guideline-directed medical therapy (GDMT) or GDMT with implantable cardioverter-defibrillator (ICD)/cardiac resynchronization therapy defibrillator (CRT-D) therapy for patients with heart failure with reduced ejection fraction (HFrEF) and left ventricular ejection fraction (LVEF) ≤35%.ObjectiveThe present study aimed to assess survival associated with GDMT or GDMT with ICD/CRT-D therapy.MethodsThis retrospective observational study included real-world de-identified data from January 1, 2016, to December 19, 2023, from 24 U.S. institutions per participating institutional agreements (egnite Database; egnite, Inc.). Patients with a diagnosis of HFrEF and an echocardiographic study documenting LVEF ≤35% were included for analysis.ResultsOf 43,591 patients with eligible index event of LVEF ≤35%, prescription history through ≥1 …
2024/1/24
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Chinese medical journal
Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation
Background Oral anti-coagulants (OAC) are the intervention for the prevention of stroke, which consistently improve clinical outcomes and survival among patients with atrial fibrillation (AF). The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in China. Methods Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation (CCC-AF) registry, guideline-recommended OAC use in eligible patients was assessed. Results A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019, of whom 38,203 were at a high risk of stroke, 9717 were at a moderate risk, and 4610 were at a low risk. On admission, only 20.0% (6075/30,420) of patients with a diagnosed AF and a high risk of stroke were taking OAC. The use of pre-hospital OAC on admission was associated with a lower risk of new-onset …
2024/1/20
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Heliyon
Time to Benefit of Colchicine in Patients with Cardiovascular Disease: A Pooled Analysis of Randomized Controlled Trials
BackgroundLow-dose colchicine has been shown to lower major adverse cardiovascular events (MACE) among those with cardiovascular disease (CVD). It remains unclear how long a CVD patient needs to live to potentially benefit from colchicine. Our study aimed to determine the time to benefit (TTB) of colchicine in individuals with CVD.MethodsLiterature searches were performed in PubMed for the cardiovascular outcome trial of colchicine in patients with CVD until October 12, 2023. The primary outcome measured was MACE. Reconstructed individual participant data (IPD) and the stratified Cox proportional hazards model were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) to estimate the efficacy of colchicine, and Weibull survival curves were fitted to estimate TTB for specific absolute risk reduction (ARR) thresholds (0.002, 0.005, and 0.01).ResultsFour trials randomizing 11,594 …
2024/4/29
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Predicting in‐hospital mortality among patients admitted with a diagnosis of heart failure: a machine learning approach
Existing risk prediction models for hospitalized heart failure patients are limited. We identified patients hospitalized with a diagnosis of heart failure between 7 May 2013 and 26 April 2022 from a large academic, quaternary care medical centre (training cohort). Demographics, medical comorbidities, vitals, and labs were collected and were used to construct random forest machine learning models to predict in‐hospital mortality. Models were compared with logistic regression, and to commonly used heart failure risk scores. The models were subsequently validated in patients hospitalized with a diagnosis of heart failure from a second academic, community medical centre (validation cohort). The entire cohort comprised 21 802 patients, of which 14 539 were in the training cohort and 7263 were in the validation cohort. The median age (25th–75th percentile) was 70 (58–82) for the entire cohort, 43.2% were female …
2024
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Percutaneous Coronary Intervention in Acute Coronary Syndrome Patients Presenting with Increased Platelet Count
Perhaps nowhere else is the tradeoff between access and quality of care as apparent as in the emergency invasive management of patients with acute coronary syndromes (ACS) and cardiogenic shock (CS). These patients require rapid hemodynamic stabilization and emergency percutaneous coronary intervention (PCI), demanding a highly skilled cardiac catheterization laboratory team. Though PCI has grown safer over the years, there remains a small inverse association between hospital and operator volume and outcomes, 1 and all else being equal, higher-volume operators and hospitals should have better outcomes, perhaps especially in these very sick patients. 2 However, all else is not equal in the setting of CS complicating ACS, in which in-hospital mortality is twice as high among those with first-medical-contactto-device time> 90 minutes compared with# 90 minutes. 3 The importance of timely access to …
2022/4/25
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Journal of the American College of Cardiology
FACTORS ASSOCIATED WITH ADHERENCE TO GUIDELINE-DIRECTED MEDICAL THERAPY (GDMT) AMONG US PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
BackgroundPoor adherence to GDMT leaves patients with HFrEF at persistent risk of clinical decline. We assessed adherence to GDMT, including quadruple therapy (QT) ie, ARNI, β-blocker, MRA, SGLT2i, and identified characteristics associated with adherence among US patients with HFrEF.MethodsPatients with HFrEF who had≥ 2 fills of GDMT from 4/2022-12/2022 were identified and described using Optum's de-identified Clinformatics® Data Mart Database. A multivariable logistic regression evaluated associations between patient characteristics and adherence ie, proportion of days covered≥ 0.8.ResultsThe analytic cohort included 47,421 patients (mean age 71 years [SD: 11], 60% male, 68% White, 12% Black). GDMT prevalence was lowest for SGLT2is (8%) and highest for β-blockers (77%); adherence was lowest for ARNI (73%) and SGLT2is (78%)(Table). Less than 1% of patients received QT and 62 …
2024/4/2
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Circulation
Shorter door-to-needle times are associated with better outcomes after intravenous thrombolytic therapy and endovascular thrombectomy for acute ischemic stroke
Background Existing data and clinical trials could not determine whether faster intravenous thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute ischemic stroke among those treated with endovascular thrombectomy (EVT). Patient-level national data can provide the required large population to study the associations between earlier IVT, versus later, with longitudinal functional outcomes and mortality in patients receiving IVT+EVT combined treatment. Methods This cohort study included older US patients (age ≥65 years) who received IVT within 4.5 hours or EVT within 7 hours after acute ischemic stroke using the linked 2015 to 2018 Get With The Guidelines–Stroke and Medicare database (38 913 treated with IVT only and 3946 with IVT+EVT). Primary outcome was home time, a patient-prioritized functional outcome. Secondary outcomes included all-cause mortality in 1 year …
2023/7/4
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Prediction models for heart failure in the community: A systematic review and meta‐analysis
Aims Multivariable prediction models can be used to estimate risk of incident heart failure (HF) in the general population. A systematic review and meta‐analysis was performed to determine the performance of models. Methods and results From inception to 3 November 2022 MEDLINE and EMBASE databases were searched for studies of multivariable models derived, validated and/or augmented for HF prediction in community‐based cohorts. Discrimination measures for models with c‐statistic data from ≥3 cohorts were pooled by Bayesian meta‐analysis, with heterogeneity assessed through a 95% prediction interval (PI). Risk of bias was assessed using PROBAST. We included 36 studies with 59 prediction models. In meta‐analysis, the Atherosclerosis Risk in Communities (ARIC) risk score (summary c‐statistic 0.802, 95% confidence interval [CI] 0.707–0.883), GRaph‐based Attention Model (GRAM; 0.791, 95 …
2023/10
Article DetailsGregg C. Fonarow
University of California, Los Angeles
European Heart Journal
Symptoms vs. pathology and outcomes in patients with reduced ejection fraction
Background After acute myocardial infarction (AMI), patients have similar mortality regardless of whether AMI is silent or not. Less is known about whether outcomes after left ventricular systolic dysfunction (LVSD) varies by absence or presence of heart failure (HF) symptoms (Stage B and C HF, respectively). Methods In Studies of Left Ventricular Dysfunction (SOLVD), patients with EF ≤35% were randomized to enalapril or placebo. We compared 4-year mortality in 2569 patients with HF symptoms (Stage C HF) enrolled in SOLVD-Treatment trial with that in 4228 patients without symptoms (Stage B) in SOLVD-Prevention trial, adjusting for 24 baseline characteristics including age, sex, race, EF, symptoms (as indexed by NYHA class). Results Patients in SOVLD-Treatment had a higher risk of death (HR, 2.63; 95% CI, 2.37–2.90; p<0.001), which remained …
2023/11
Article DetailsGregg C. Fonarow
University of California, Los Angeles
JAMA cardiology
Realigning Priorities in the Evaluation and Management of Patients With Heart Failure
In this issue of JAMA Cardiology, Perera and coauthors1 report that myocardial viability status has no influence on the outcomes associated with either percutaneous revascularization or optimal medical therapy in patients with heart failure and reduced ejection fraction (HFrEF). An accompanying Invited Commentary by Panza2 suggests that viability assessment should be more selectively applied to inform a risk/benefit discussion in complex cases being considered for revascularization.There is another lesson that emanates from the results of the STICH3 and REVIVED-BCIS2 trials4 involving the sequence of evaluation and management decisions that often occur in patients hospitalized with HFrEF. After initial diuresis and stabilization, there is often a clinical imperative to perform catheterization to identify coronary artery disease (CAD). This may be amplified by findings of elevated highsensitivity troponin levels …
2023/12/1
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Journal of Cardiac Failure
Rapidly Improving Health-Related Social Needs Assessment Through A National Collaborative
IntroductionHeart Failure (HF) is projected to impact over 8 million people by 2030. The complexity of HF is compounded by adverse effects of social determinants of health (SDOH), defined as "conditions in which people are born, grow, work, live, age, and the wider set of forces and systems shaping the conditions of daily life". A 2020 study of Medicare beneficiaries hospitalized with HF found that patients burdened by a SDOH factor were associated with almost 3 times the risk of 90‐day mortality, compared to those without these factors. The American Heart Association recognizes the adverse impact of SDOH on HF patients and is driving efforts to improve assessing and addressing these factors.HypothesisBy leading IMPLEMENT-HF (I-HF), a national quality improvement initiative with a component focused on improving organizations' assessment of health-related social needs (HRSN), we aim to increase the …
2023/4/1
Article DetailsGregg C. Fonarow
University of California, Los Angeles
medRxiv
Monitoring Heart Failure Patients with Mobile Health Technologies: Outcomes from a 180-day Prospective Study
Mobile health (mHealth) methods have grown in popularity in preventative medicine due to their convenience, cost, and ability to acquire actionable data. At the same time, the burden of many diseases has grown due to their prevalence and high rates of morbidity and mortality. To combat this burden, mHealth can be customized to improve adherence to recommended regimens and decrease doctor or hospital visits for patients and their families. Heart failure (HF) is a disease with an especially high burden for which mHealth can be used to promote adherence to advised care plans with the goal of decreasing exacerbations and their associated urgent and emergency care visits. Our study compared adherence to different mHealth monitoring regimens that used activity trackers, scales, and a mobile app with gamification features and a financial incentive. In a prospective analysis of 111 HF patients monitored for 180 days, we found that a regimen including a mobile app with a gamified financial incentive led to significantly higher adherence to activity tracker (95% vs. 72.2%, p=0.0101) and weight (87.5% vs. 69.4%, p=0.0016) monitoring compared to a regimen that included the monitoring devices alone. Our findings indicate that mobile apps with added engagement features can be useful tools to reduce temporal adherence decline and may thus increase the impact of mHealth driven interventions.
2023
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Journal of Cardiopulmonary Rehabilitation and Prevention
Availability and Use of In-Person and Virtual Cardiac Rehabilitation Among US Medicare Beneficiaries: A Post-Pandemic Update
METHODSWe accessed Medicare FFS claims through the Virtual Research Data Center of the Centers for Medicare and Medicaid Services. Claims for CR services between January 1, 2019, and September 31, 2022, were identified in outpatient files using Current Procedural Terminology codes 93797 and 93798. Virtual or hybrid CR sessions were identified by claims with “CR” or “DR” modifiers (indicating disaster or emergency-related claims). To assess the impact of the pandemic on CR availability and use, we compared the rate of participation and initiation of CR in the Medicare FFS population in two 6-mo study periods: September 2019 to February 2020 (pre-pandemic, period 1) and April 2022 to September 2022 (most recent data available, period 2). As in prior work, 4 we used a 12-mo lookback period to identify patients eligible for CR within each of the study periods: patients with claims for acute …
2023/7/1
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Stroke and Vascular Neurology
Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision …
Background Given the swift advancements in artificial intelligence (AI), the utilisation of AI-based clinical decision support systems (AI-CDSSs) has become increasingly prevalent in the medical domain, particularly in the management of cerebrovascular disease.Aims To describe the design, rationale and methods of a cluster-randomised multifaceted intervention trial aimed at investigating the effect of cerebrovascular disease AI-CDSS on the clinical outcomes of patients who had a stroke and on stroke care quality.Design The GOLDEN BRIDGE II trial is a multicentre, open-label, cluster-randomised multifaceted intervention study. A total of 80 hospitals in China were randomly assigned to the AI-CDSS intervention group or the control group. For eligible participants with acute ischaemic stroke in the AI-CDSS intervention group, cerebrovascular disease AI-CDSS will provide AI-assisted imaging analysis, auxiliary …
2023/9/12
Article DetailsGregg C. Fonarow
University of California, Los Angeles
European Heart Journal
A national heart failure initiative is associated with improved use of quadruple guideline-directed medical therapy
Background Heart Failure (HF) is projected to impact over 8 million people in the US by 2030. The 2022 AHA/ACC/HFSA Guideline for the Management of HF recommend four foundational medication classes for treating HFrEF patients: RAAS inhibitors, preferably angiotensin receptor/neprilysin inhibitor (ARNi), evidence-based beta-blockers (EBBB), sodium-glucose cotransporter-2 inhibitor (SGLT2i) and mineralocorticoid receptor antagonist (MRA) referred to as Quadruple Guideline-Directed Medical Therapy (Q-GDMT). Q-GDMT has shown an estimated 73% relative and 26% absolute reduction in all-cause mortality over 2 years. Yet, despite remarkable clinical potential, these therapies are patently underutilized in clinical practice. It is unknown whether an implementation science strategy may enhance adherence to Q-GDMT for HF. Methods IMPLEMENT-HF (IHF) is a …
2023/11
Article DetailsGregg C. Fonarow
University of California, Los Angeles
American heart journal
Taking the next step in cardiovascular risk reduction: Integrating heart failure and peripheral arterial disease prevention
Taking the next step in cardiovascular risk reduction: Integrating heart failure and peripheral arterial disease prevention — Johns Hopkins University Skip to main navigation Skip to search Skip to main content Johns Hopkins University Home Johns Hopkins University Logo Home Profiles Research units Research output Search by expertise, name or affiliation Taking the next step in cardiovascular risk reduction: Integrating heart failure and peripheral arterial disease prevention Daniel S. Matasic, Roger S. Blumenthal, Gregg C. Fonarow, Martha Gulati School of Medicine Research output: Contribution to journal › Editorial › peer-review Overview Original language English (US) Pages (from-to) 176-178 Number of pages 3 Journal American heart journal Volume 266 DOIs https://doi.org/10.1016/j.ahj.2023.07.004 State Published - Dec 2023 ASJC Scopus subject areas Cardiology and Cardiovascular Medicine Access …
2023/12
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Journal of the American College of Cardiology
RISK FACTORS AND PREVALENCE TRENDS FOR APPARENT TREATMENT-RESISTANT HYPERTENSION; A POPULATION BASED STUDY IN USA FROM 2004-2018
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2023/3/7
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Heart Failure
Neighborhood household income and trends in 30-day readmission for patients with heart failure
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2023/1/1
Article DetailsOther articles from Chinese medical journal journal
ben wang
Huazhong University of Science and Technology
Chinese Medical Journal
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2024/1/9
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Georgia Institute of Technology
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2024/1/31
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Western University
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2024/1/20
Article DetailsProf Dr Yusuf Yılmaz
Marmara Üniversitesi
Chinese Medical Journal
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2024/2/6
Article DetailsSu Bin
Zhejiang University
Chinese Medical Journal
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2024/3/20
Article DetailsPeige Song
Zhejiang University
Chinese Medical Journal
Associations between parental adherence to healthy lifestyles and cognitive performance in offspring: A prospective cohort study in China
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2024/3/20
Article DetailsFeng GAO
Sun Yat-Sen University
Chinese Medical Journal
Knowledge-embedded spatio-temporal analysis for euploidy embryos identification in couples with chromosomal rearrangements
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2023
Article DetailsXiao Tan
Uppsala Universitet
Chinese Medical Journal
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2024/3/13
Article DetailsLanjuan Li
Zhejiang University
Chinese Medical Journal
Hypertension and NAFLD risk: Insights from the NHANES 2017-2018 and Mendelian randomization analyses
Background Hypertension and non-alcoholic fatty liver disease (NAFLD) share several pathophysiologic risk factors, and the exact relationship between the two remains unclear. Our study aims to provide evidence concerning the relationship between hypertension and NAFLD by analyzing data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 and Mendelian randomization (MR) analyses. Methods Weighted multivariable-adjusted logistic regression was applied to assess the relationship between hypertension and NAFLD risk by using data from the NHANES 2017-2018. Subsequently, a two-sample MR study was performed using the genome-wide association study (GWAS) summary statistics to identify the causal association between hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), and NAFLD. The primary inverse variance weighted (IVW) and other …
2024/2/20
Article DetailsJorge Chavarro
Harvard University
Chinese Medical Journal
Associations between parental adherence to healthy lifestyles and cognitive performance in offspring: A prospective cohort study in China
Background Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early childhood. This study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in China. Methods We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies. A healthy parental lifestyle score (ranged 0-5) was constructed based on the following five modifiable lifestyle factors: Smoking, drinking, exercise, sleep, and diet. Generalized estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years (2012, 2014, 2016, and 2018). Results Offspring in the top tertile of parental healthy …
2024/3/20
Article DetailsXia Jiang
Karolinska Institutet
Chinese Medical Journal
Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses
Background While type 2 diabetes mellitus (T2DM) is considered a putative causal risk factor for coronary artery disease (CAD), the intrinsic link underlying T2DM and CAD is not fully understood. We aimed to highlight the importance of integrated care targeting both diseases by investigating the phenotypic and genetic relationships between T2DM and CAD. Methods We evaluated phenotypic associations using data from the United Kingdom Biobank (N = 472,050). We investigated genetic relationships by leveraging genomic data conducted in European ancestry for T2DM, with and without adjustment for body mass index (BMI) (T2DM: Ncase/Ncontrol = 74,124/824,006; T2DM adjusted for BMI [T2DMadjBMI]: Ncase/Ncontrol = 50,409/523,897) and for CAD (Ncase/Ncontrol = 181,522/984,168). We performed additional analyses using genomic data conducted in multiancestry individuals for T2DM (Ncase/Ncontrol …
2024/3/5
Article DetailsLu Qi
Harvard University
Chinese Medical Journal
Birth weight, ideal cardiovascular health metrics in adulthood, and incident cardiovascular disease
Background:Prenatal and postnatal factors may have joint effects on cardiovascular health, and we aimed to assess the joint association of birth weight and ideal cardiovascular health metrics (ICVHMs) prospectively in adulthood with incident cardiovascular disease (CVD).Methods:In the UK Biobank, 227,833 participants with data on ICVHM components and birth weight and without CVD at baseline were included. The ICVHMs included smoking, body mass index, physical activity, diet information, total cholesterol, blood pressure, and hemoglobin A1c. The Cox proportional hazards model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) in men and women.Results:Over a median follow-up period of 13.0 years (2,831,236 person-years), we documented 17,477 patients with incident CVD. Compared with participants with birth weights of 2.5–4.0 kg, the HRs [95% CIs] of CVD among …
2024/3/13
Article DetailsWeili Yan
Fudan University
Chinese Medical Journal
Temporal trend in mortality due to congenital heart disease in China from 2008 to 2021
Background:Congenital heart disease (CHD) is a leading cause of birth defect-related mortality. However, more recent CHD mortality data for China are lacking. Additionally, limited studies have evaluated sex, rural–urban, and region-specific disparities of CHD mortality in China.Methods:We designed a population-based study using data from the Dataset of National Mortality Surveillance in China between 2008 and 2021. We calculated age-adjusted CHD mortality using the sixth census data of China in 2010 as the standard population. We assessed the temporal trends in CHD mortality by age, sex, area, and region from 2008 to 2021 using the joinpoint regression model.Results:From 2008 to 2021, 33,534 deaths were attributed to CHD. The period witnessed a two-fold decrease in the age-adjusted CHD mortality from 1.61 to 0.76 per 100,000 persons (average annual percent change [AAPC]=− 5.90%). Females …
2024/4/25
Article DetailsChangzheng Yuan
Harvard University
Chinese Medical Journal
Associations between parental adherence to healthy lifestyles and cognitive performance in offspring: A prospective cohort study in China
Background Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early childhood. This study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in China. Methods We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies. A healthy parental lifestyle score (ranged 0-5) was constructed based on the following five modifiable lifestyle factors: Smoking, drinking, exercise, sleep, and diet. Generalized estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years (2012, 2014, 2016, and 2018). Results Offspring in the top tertile of parental healthy …
2024/3/20
Article DetailsGuanbin Li (李冠彬)
Sun Yat-Sen University
Chinese Medical Journal
Knowledge-embedded spatio-temporal analysis for euploidy embryos identification in couples with chromosomal rearrangements
Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy neonatal. Some algorithms have been used to assess the ploidy status of embryos derived from couples with normal chromosome, who subjected to preimplantation genetic testing for aneuploidy (PGT-A) treatment. However, it is currently unknown whether artificial intelligence model can be used to assess the euploidy status of blastocyst derived from populations with chromosomal rearrangement.Methods:From February 2020 to May 2021, we collected the whole raw time-lapse videos at multiple focal planes from in vitro cultured embryos, the clinical information of couples, and the comprehensive chromosome screening results of those blastocysts that had received PGT treatment. Initially, we developed a novel deep learning model called the Attentive Multi-Focus …
2023
Article DetailsYan Li
Icahn School of Medicine at Mount Sinai
Chinese Medical Journal
Trends in mortality due to tracheal, bronchial, and lung cancer across the BRICS: An age–period–cohort analysis based on the Global Burden of Disease Study 1990–2019
Background: Tracheal, bronchus, and lung cancer (TBL) is a major cause of mortality and top contributor to productivity loss in large emerging economies such as the BRICS (Brazil, Russia, India, China, and South Africa). We examined the time trends of TBL mortality across the BRICS to better understand the disease burden in these countries and inform public health and healthcare resource allocation.Methods: TBL mortality-related data between 1990 and 2019 were obtained from the Global Burden of Disease Study 2019 and analyzed using age–period–cohort models. Net drift (local drift) was used to describe the expected age-adjusted TBL mortality rate over time overall (each age group); the longitudinal age curve was used to reflect the age effect; the period rate ratios (RRs) were used to reflect the period effect; and the cohort RR was used to reflect the cohort effect. Results: In 2019, there were 958.3 …
2024/2/5
Article DetailsYuqin Yao
Sichuan University
Chinese Medical Journal
Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses
Background While type 2 diabetes mellitus (T2DM) is considered a putative causal risk factor for coronary artery disease (CAD), the intrinsic link underlying T2DM and CAD is not fully understood. We aimed to highlight the importance of integrated care targeting both diseases by investigating the phenotypic and genetic relationships between T2DM and CAD. Methods We evaluated phenotypic associations using data from the United Kingdom Biobank (N = 472,050). We investigated genetic relationships by leveraging genomic data conducted in European ancestry for T2DM, with and without adjustment for body mass index (BMI) (T2DM: Ncase/Ncontrol = 74,124/824,006; T2DM adjusted for BMI [T2DMadjBMI]: Ncase/Ncontrol = 50,409/523,897) and for CAD (Ncase/Ncontrol = 181,522/984,168). We performed additional analyses using genomic data conducted in multiancestry individuals for T2DM (Ncase/Ncontrol …
2024/3/5
Article DetailsAimin Wang
Peking University
Chinese Medical Journal
Non-invasive imaging of pathological scars using a portable handheld two-photon microscope
Background:Pathological scars are a disorder that can lead to various cosmetic, psychological, and functional problems, and no effective assessment methods are currently available. Assessment and treatment of pathological scars are based on cutaneous manifestations. A two-photon microscope (TPM) with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in vivo. This study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar patients.Methods:Fifteen patients with pathological scars and three healthy controls were recruited. Imaging was performed using a portable handheld TPM. Five indexes were extracted from two dimensional (2D) and three dimensional (3D) perspectives, including collagen depth, dermo …
2024/2/5
Article DetailsXujie Liu ( 刘旭杰)
Harvard University
Chinese Medical Journal
Perspectives of genetic management strategy for inherited cardiovascular diseases in China
Inherited cardiovascular diseases (CVDs) threaten human health and pose an enormous economic burden worldwide. Genetic alteration is a major risk factor for many CVDs. These disorders are usually controlled by a pair of alleles, affecting offspring according to the Mendelian principle, regardless of isolated primary damage or secondary injury from other syndromes or deficiency. To date, there are hundreds of inherited CVDs. With advances in nextgeneration sequencing (NGS) technologies, rapid and accurate molecular diagnosis of patients with inherited CVDs is clinically practical. Besides, great improvements have been made in recent years, and targeted therapy and assist devices have been used in clinical practice. Yet there is still no totally efficient strategy for dealing with inherited CVDs. Accordingly, there is an urgent need to develop better therapeutic strategies for treating inherited CVDs.[1]Heritable …
2023/9/5
Article DetailsGregg C. Fonarow
University of California, Los Angeles
Chinese medical journal
Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation
Background Oral anti-coagulants (OAC) are the intervention for the prevention of stroke, which consistently improve clinical outcomes and survival among patients with atrial fibrillation (AF). The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in China. Methods Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation (CCC-AF) registry, guideline-recommended OAC use in eligible patients was assessed. Results A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019, of whom 38,203 were at a high risk of stroke, 9717 were at a moderate risk, and 4610 were at a low risk. On admission, only 20.0% (6075/30,420) of patients with a diagnosed AF and a high risk of stroke were taking OAC. The use of pre-hospital OAC on admission was associated with a lower risk of new-onset …
2024/1/20
Article Details